The “Spirit of the East” is still sailing the world, but the Montesquieu group of “bespoke collection” wines from Napa Valley and beyond has capsized and is flailing about for a way to right itself with Chapter 11 filings in the Delaware District of U.S. Bankruptcy Court. Montesquieu Inc., a Delaware Corporation, filed for bankruptcy […]
The Mendelian Randomization by Millwood et al.: Observations and Expressions of Concern
May 6, 2019
Link to article 2, explaining Mendelian Randomization The recent population study of adults in China that found no cardio-protective benefits of moderate alcohol consumption should be re-examined in the context of methodological and confounding factors not addressed in the published paper. Published in early April by The Lancet, the study provoked sensational headlines among the […]
Background: Mendelian Randomization (MR): A new statistical regime to estimate causation
Link to main article Mendelian Randomization (MR) is a relatively new statistical method designed to provide an estimate of a causal connection between the effects of an observable exposure to a risk factor (such as alcohol consumption) on a specific outcome (such as cardiovascular events like stroke and heart attacks). It is necessary to note […]